J Clin Endocrinol Metab 89, 5387–5391.īiancuzzo RM, Young A, Bibuld D, Cai MH, Winter MR, Klein EK et al. Vitamin D2 is much less effective than vitamin D3 in humans. J Am Acad Dermatol 57, 588–593.Īrmas LA, Hollis BW, Heaney RP (2004). ![]() Ultraviolet-B radiation increases serum 25-hydroxyvitamin D levels: the effect of UVB dose and skin color. This trial was registered at as DRKS00000195.Īrmas LA, Dowell S, Akhter M, Duthuluru S, Huerter C, Hollis BW et al. We are the first to demonstrate in humans that the bioavailability of vitamin D 2 from vitamin D 2-enhanced button mushrooms via UV-B irradiation was effective in improving vitamin D status and not different to a vitamin D 2 supplement. The serum 25OHD concentrations in the mushroom and supplement groups rose significantly and similarly over the study period by 3.9 nmol/l (95% confidence interval (95% CI): 2.9, 4.8) and by 4.7 nmol/l per week (95% CI: 3.8, 5.7), respectively. Results:Īfter 2 weeks, serum 25OHD was significantly higher in the mushroom than in the placebo group ( P=0.001). They received during winter (a) 28 000 IU (700 μg) vitamin D 2 via the experimental soup, or (b) 28 000 IU vitamin D 2 via a supplement or (c) placebo, respectively. In this 5-week, single-blinded, randomized, placebo-controlled trial, 26 young subjects with serum 25-hydroxyvitamin D (25OHD) ⩽50 nmol/l were randomly assigned into three groups ((a) mushroom, (b) supplement and (c) placebo). Subjects/Methods:įresh mushrooms were irradiated with an UV-B dose of 1.5 J/cm 2, increasing vitamin D 2 content from <1 to 491 μg/100 g and made to an experimental soup. Our objective was to investigate the bioavailability of vitamin D 2 from vitamin D 2-enhanced mushrooms by UV-B in humans, and comparing it with a vitamin D 2 supplement. Objectives:Mushrooms contain very little or any vitamin D 2 but are abundant in ergosterol, which can be converted into vitamin D 2 by ultraviolet (UV) irradiation.
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